Papers

van Weperen VYH, Hoang JDH, Jani N, Khaky A, Herring N, Smith C, Vaseghi M. Circulating noradrenaline leads to release of neuropeptide Y from cardiac sympathetic nerve terminals via activation of β-adrenergic receptors. J. Physiol. 2024. https://doi.org/10.1113/JP285945

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‌Dusi V, Vaseghi M. Neuronal sympathetic block for ventricular arrhythmias: one size may not fit all. Europace. 2023:25.

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van Weperen VYH, Vaseghi M. Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps. Front. Neurosci. 2023:17. 

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‌van Weperen VYH, Ripplinger CM, Vaseghi M. Autonomic control of ventricular function in health and disease: current state of the art. Clin Auton Res 2023:1-27. 

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‌‌Sridharan A, Tang A, Sorg JM, Hoftman NN, Lee JM, Yanagawa J, Vaseghi M. Effect of Bilateral Cardiac Sympathetic Denervation on Burden of Premature Ventricular Contractions. Circ Arrhythm Electrophysiol 2023;0:e011546

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‌‌Nguyen DT, Bilchick KC, Narayan SM, Chung MK, Thomas KL, Laurita KR, Vaseghi M, Sandhu R, Chelu MG, Kannankeril PJ, Packer DL, McManus DD, Verma A, Singleton M, Tarakji K, Al-Khatib SM, Kaltman JR, Balijepalli RC, Van Hare GF, Hurwitz JL, Russo AM, Kusumoto FM, Albert CM. Opportunities and challenges in heart rhythm research: Rationale and development of an electrophysiology collaboratory. Heart rhythm. 2022:19. 

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Zeppenfeld K, Wijnmaalen AP, Ebert M, Baldinger SH, Berruezo A, Catto V, Vaseghi M, Arya A, Kumar S, de Riva M, Deneke T, Gaspar T, Soejima K, van Rein N, Tedrow UB, Piorkowski C, Shivkumar K, Carbucicchio C, Hindricks G, Stevenson WG., Clinical Outcomes in Patients with Dilated Cardiomyopathy and Ventricular Tachycardia. J Am Coll Cardiol 2022;80:1045-56.

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Devarajan A, Wang K, Shannon K, Su Y, Verheyden J, Sun X & Vaseghi M. Convergent cardiorespiratory neurons represent a significant portion of cardiac and respiratory neurons in the vagal ganglia. Front Cardiovasc Med 2022

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‌Tamirisa KP, Dye C, Bond RM, Hollier LM, Marinescu K, Vaseghi M, Russo AM, Gulati M, Volgman AS., ‌Arrhythmias and heart failure in pregnancy: a dialogue on  multidisciplinary collaboration. J Cardiovasc Dev Dis 2022;9: 199.

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Sridharan A, Vaseghi M., Uni vs. bi: what to do when they don’t see eye to eye. Heart Rhythm 2022; 19:1074-1075

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Hoang JD, Yamakawa K, Rajendran P, Chan CA, Yagishita D, Nakamura K, Lux RL, Vaseghi M.,‌Pro-Arrhythmic Effects of Sympathetic Activation are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts. JACC Clin Electrophysiol 2022; 8:513-525.

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Salavatian S, Hoang JD, Yamaguchi N, Lokhandwala ZA, Swid MA, Armour JA, Ardell JL, Vaseghi M., Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia. JCI Insight 2022; 7:e155747.

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‌Tamirisia KP, Elkayam U, Briller JE, Mason PK, Pillarisetti K, Merchant FM, Patel H. Lakkireddy DR, Russo AM, Volgman AS, Vaseghi M., Arrhythmias in pregnancy. JACC Clin Electrophysiol 2022;8:120-135.

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Dusi V, Gornbein J, Do DH, Sorg JM, Khakpour H, Krokhaleva Y, Ajijola OA, Macias C, Bradfield JS, Buch E, Fujimura OA, Boyle NG, Yanagawa J, Lee JM, Shivkumar K, Vaseghi M., Arrhythmic risk profile and outcomes of patients undergoing cardiac sympathetic denervation for recurrent monomorphic ventricular tachycardia after ablation. J Am Heart Assoc 2021;10:e018371.

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‌Elliott IA, DeJesus M, Dobaria V, Vaseghi M, Ajijola OA, Shivkumar K, Hoftman NN, Benharash P, Lee JM, Yanagawa J., Minimally invasive bilateral stellate ganglionectomy for refractory ventricular tachycardia. Ann Thorac Surg 2020;29:S0003-4975(20)31902-0.

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Devarajan A, Vaseghi M., Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights. Redox Biol 2021;38

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‌ Wu P, Vaseghi M., The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure. Pacing Clin Electrophysiol 2020;43:172-180.

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Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, Lim HS, Lip GYH, Nava-Townsend S, Pak HN, Rodríguez Diez G, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ; ESC Scientific Document Group, Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Pava Molano LF, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillai J, Vidal A, Deneke T, Hindricks G, Leclercq C., European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Europace 2020;22:1147-48 (simultaneous publication in Heart Rhythm)

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‌Chan SA, Vaseghi M, Kluge N, Shivkumar K, Ardell JL, Smith C., Fast in vivo detection of myocardial norepinephrine levels in the beating porcine heart. Am J Phys Heart Circ Physiol 2020;318:H1091-99.

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‌Hoang JD, Salavatian S, Yamaguchi N, Swid MA, David H, Vaseghi M., Cardiac Sympathetic Activation Circumvents High Dose Beta Blocker Therapy in Part Through Neuropeptide-Y Release. JCI Insight 2020; 5:e135519

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Dusi V, Sorg. JM, Gornbein JM, Gima, Yanagawa J, Lee JM, Vecerek N, Vaseghi M, Bradfield JS, Ferrari GM, Shivkumar K, Ajijola OA., Prognostic impact of atrial rhythm and dimension in patients with structural heart disease undergoing cardiac sympathetic denervation for ventricular arrhythmias. Heart Rhythm 2020;17:714-20.

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‌Bradfield JS, Hayase J Liu K, Moriarty J, Kee ST, Do D, Ajijola OA, Vaseghi M, Gima J, Sorg J, Cote S, Pavez G, Buch E, Khakpour H, Krokhaleva Y, Macias C, Fujimura O, Boyle NG, Shivkumar K., Renal denervation as adjunctive therapy to cardiac sympathetic denervation for ablation of refractory ventricular tachycardia. Heart Rhythm 2020; 17:220-227.

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Volgman AS, Bairey Merz CN, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Pepine CJ, Vaseghi M, Waldo AL, Wenger NK, Russo AM., ‌Sex and Race/Ethnicity Differences in Atrial Fibrillation. J Am Coll Cardiol 2019;74:2812-15.

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‌Salavatian S. Yamaguchi N, Hoang J, Lin N, Patel S, Ardell JL, Armour JAA, Vaseghi M., Premature ventricular contractions activate vagal cardiac afferent neurons and alter autonomic tone: potential implication for premature ventricular contraction-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 2019, 317:H607-H616.

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Krokhaleva Y, Vaseghi M., Update on prevention and treatment of sudden cardiac arrest. Trends in Cardiovasc Med 2019; 29:394-400.

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‌Vergara P, Tzou WS, Tung R, Brombin C, Nonis A, Vaseghi M, Frankel DS, DiBiase L, Tedrow U, Mathuria N, Nakahara S, Tholakanahalli V, Bunch TJ, Weiss JP, Dickfeld T, Lakkireddy D, Burkhardt JD, Santangeli P, Callans D, Natale A, Marchlinski F, Stevenson WG, Shivkumar K, Sauer WH, Della Bella P., Predictive score for identifying survival and recurrence risk profiles in patients undergoing ventricular tachycardia ablation. Circ Arrhythm Electrophysiol 2018, 11: e006730.

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Vaseghi M, Hu TY, Tung R, Vergara P, Frankel DS, Di Biase L, Tedrow UB, Gornbein JA, Yu R, Mathuria N, Nakahara S, Tzou WS, Sauer WH, Burkhardt DJ, Tholakanalli VN, Dickfeld TM, Weiss JP, Bunch TJ, Reddy M, Callans DJ, Lakkireddy DR, Natale A, Marchlinski FE, Stevenson WG, Della Bella P, Shivkumar K., Outcomes of catheter ablation of ventricular tachycardia based on etiology of nonischemic heart disease: An international ventricular tachycardia ablation center collaborative study.  JACC Clin Electrophysiol 20184:1141-1150.

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‌Huang WA, Dunipace MS, Sorg JM, Vaseghi M., Liver disease as a predictor of new-onset atrial fibrillation. J Am Heart Assoc 2018, 7(15): e008703

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‌Kung GL, Vaseghi M, Gahm JK, Shevtsov J, Garfinkel A, Shivkumar K, Ennis DB., Microstructural infarct border zone remodeling in the post-infarct swine heart measured by diffusion tensor MRI. Front Physiol 2018; 9:826

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‌Yamaguchi N, Yamakawa K, Rajendran PS, Takamiya T, Vaseghi M., Anti-arrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction. Heart Rhythm 2018;15:1214-1222

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‌Hoang J, Vaseghi M., A novel mechanism for regulation of cardiac Ca2+ current by estradiol: cAMPing out at the basal epicardium. Heart Rhythm 2018; 15:750-751.

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‌Vakil K, Garcia S. Tung R, Vaseghi M, Tedrow U, Della Bella P, Frankel DS, Vergara P, Di Biase L, Nagashima K, Nakahara S, Tzou WS, Burkhardt JD, Dickfeld T, Weiss JP, Bunch J, Callans D, Lakkireddy D, Natale A, Sauer WH, Stevenson WG, Marchlinski F, Shivkumar K, Tholakanahalli VN.. Ventricular tachycardia ablation in the elderly: An International Ventricular Tachycardia Collaborative Group analysis. Circ Arrhythm Electrophysiol 2017;10(12):e005332.

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‌Chadda KR, Ajijola OA, Vaseghi M, Shivkumar K, Huang CL, Jeevaratnam K., Ageing, the autonomic nervous system, and arrhythmias: from brain to heart. Ageing Res Rev 2018;48: 40-50.

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‌Krokhaleva Y, Vaseghi M., How to evaluate for and manage inflammatory and infiltrative cardiomyopathies that require ventricular tachycardia ablation. Curr Cardiovasc Risk Rep 2017; 11:1-13.

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Li A, Hayase J, Do D, Buch E, Vaseghi M, Ajijola OA, Macias C, Krokhaleva A, Khakpour H, Boyle NG, Benharash P, Biniwale R, Shivkumar K, Bradfield JS., Hybrid surgical vs. percutaneous access epicardial ventricular tachycardia ablation. Heart Rhythm 2018;15:512-19.

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‌Do DH, Bradfield J, Ajijola OA, Vaseghi M, Le J, Rahman S, Mahajan A, Nogami A, Boyle NG, Shivkumar K., Thoracic epidural anesthesia can be effective for short-term management of ventricular tachycardia storm. J Am Heart Assoc 2017; 6:e007080

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I‌rie T*, Yamakawa K*, Hamon D, Nakamura K, Shivkumar K, Vaseghi M., Cardiac sympathetic innervation via the middle cervical ganglia and anti-arrhythmic mechanism of bilateral stellectomy. Am J Physiol Heart Circ Physiol 2017;312:H392-H405.

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‌Vaseghi M, Salavatian SS, Rajendran PS, Yagishita P, Woodward WR, Hamon D, Yamakawa K, Irie T, Habecker BA, Shivkumar K., Parasympathetic dysfunction and anti-arrhythmic effect of vagal nerve stimulation following myocardial infarction. JCI Insight 2017;2 (16): e86715. 

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‌Vaseghi M, Barwad P, Corrales Malavassi FJ, Tandri H, Mathuria N, Shah R, Sorg JM, Gima J, Mandal K, Saenz Morales LC, Lokhandwala Y, Shivkumar K., Cardiac sympathetic denervation for refractory ventricular arrhythmias. J Am Coll Cardiology 2017;69:3070-3080

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‌Guerra F, Bonelli P, Flor M, Cipoletta L, Carbucicchio C, Izquierdo M, Kozluk E, Vaseghi M, Shivkumar K, Patani F, Cupido C, Pala S, Luiz-Granell R, Ferrero A, Tondo C, Capucci A., Circannual Pattern and TEMPerature-Related Incidence of Electrical STorm: The TEMPEST Study. Circ Arrhythm Electrophysiol 2017;10:e004634

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‌Saenz LC, Corrales FM, Bautista W, Traina M, Meymandi S, Rodriguez DA, Tellez LJ, Vaseghi M, Garcia F, Shivkumar K, Bradfield JS., Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease. Heart Rhythm 2016;13:138-94.

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‌Huang WA, Shivkumar K, Vaseghi M., Device-based autonomic modulation in arrhythmia patients: the role of vagal nerves stimulation. Curr Treat Options Cardiovasc Med 2015; 17:379.

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‌Yamakawa K, Howard-Quijano K, Zhou W, Rajendran PS, Yagishita D, Vaseghi M, Ajijola OA, Armour JA, Shivkumar K, Ardell JL, Mahajan A., Central vs. peripheral neuraxial sympathetic control of porcine ventricular electrophysiology. Am J Physiol Heart and Circ Physiol 2016;310:R414-21.

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Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Amour JA, Ardell JL, Shivkumar K., Myocardial infarction induces structural and functional remodeling of the intrinsic cardiac nervous system. J Physiol 2016;594:321-41.

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‌Yamakawa K, Rajendran PS, Takamiya T, Yagishita D, So EL, Mahajan A, Shivkumar K, Vaseghi M., Vagal nerve stimulation activates vagal afferent fibers that reduce cardiac efferent parasympathetic effects. Am J Physiol Heart Circ Physiol 2015;309:H1579-90.

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‌Watanabe A, Seki A, Fishbein MC, Shivkumar K, Vaseghi M., Arrhythmogenic right ventricular cardiomyopathy: electroarchitecture of the substrate. Heart Rhythm Case Reports, 2016;2:47-51.

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Vaseghi M*, Tung R*, Frankel DS, Vergara P, Di Biase L, Nagashima K, Yu R, Vangala S, Tseng CH, Choi EK, Khurshid S, Patel M, Mathuria N, Nakahara S, Tzou WS, Sauer WH, Vakil K, Tedrow U, Burkhardt JD, Tholakanahalli VN, Saliaris A, Dickfeld T, Weiss JP, Bunch TJ, Reddy M, Kanmanthareddy A, Callans DJ, Lakkireddy D, Natale A, Marchlinski F, Stevenson WG, Della Bella P, Shivkumar K., Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study. Heart Rhythm 2015;12:1997-2007‌

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‌Irie T, Yu R, Bradfield JS, Vaseghi M, Buch EF, Ajijola O, Macias C, Fujimura O, Mandapati R, Boyle NG, Shivkumar K, Tung R., Relationship between sinus rhythm late activation zones and critical sites of scar-related ventricular tachycardia: systematic analysis of isochronal late activation mapping. Circ Arrhythm Electrophysiol 2015; 8:390-9.

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‌ Huang WA, Shivkumar K, Vaseghi M., Device-based autonomic modulation in arrhythmia patients: the role of vagal nerves stimulation. Curr Treat Options Cardiovasc Med 2015; 17:379.

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‌Mao J, Moriarty J, Mandapati R, Shivkumar K, Vaseghi M., Catheter ablation of accessory pathways near the coronary sinus, value of defining coronary arterial anatomy. Heart Rhythm 2015;12:508-14

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‌Yu R, Ma S, Tung R, Stevens S, Macias C, Bradfield J, Buch E, Vaseghi M, Fujimura O, Gornbein J, Mandapati R, Shivkumar K, Boyle NG., Catheter ablation of scar-based ventricular tachycardia: relationship of procedure duration to outcomes and hospital mortality. Heart Rhythm 2015;12;86-94.

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‌Yagishita D, Chui RW, Yamakawa K, Rajendran PS, Ajijola OA, Nakamura K, So EL, Mahajan A, Shivkumar K, Vaseghi M., Sympathetic nerve stimulation, not circulating norepinephrine, modulated T-peak to T-end interval by increasing global dispersion of repolarization. Circ Arrhythm Electrophysiol 2015;9:174-185.

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‌Yamakawa K, So E, Rajendran P, Hoang J, Makkar N, Mahajan A, Shivkumar K, Vaseghi M., Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium. Am J Physiol Heart Circ Physiol 2014;307:H722-31.

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‌Canan T, Vaseghi M, Girsky MJ, Yang EH., A complex rhythm treated simply: fascicular ventricular tachycardia. Am J Med 2014;127:601-04.

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Vaseghi M, Gima J, Kanaan C, Ajijola OA, Marmureanu A, Mahajan A, Shivkumar K., Cardiac sympathetic denervation in patients with refractory ventricular tachycardia or electrical storm: intermediate and long term follow up. Heart Rhythm 2014;11:360-6. 

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