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As cardiologists, we are witness to the devastating effects of cardiovascular disease and recurrent arrhythmias, including sudden death, on patients and their families. Our laboratory has a keen interest in neural mechanisms and drivers of cardiac dysfunction and ventricular arrhythmias. Cardiovascular disease causes scar formation in the heart and pathological changes in the heart’s autonomic nervous system, which predispose to abnormal heart rhythms, including atrial and ventricular arrhythmias, and lead to progression of heart failure.

Our lab focuses on identifying the underlying mechanisms and triggers for this neural remodeling and finding ways to prevent arrhythmias and treat heart failure by exploring a variety of neuromodulatory approaches. We also have a special interest in better understanding differences in the presentation and mechanisms of arrhythmias and heart disease in men vs. women and finding therapies to improve women’s cardiovascular health. 

Our research utilizes a multiprong approach to delineate and evaluate the entire cardiac neuraxis utilizing cutting edge techniques, including in vivo and ex vivo techniques such as cardiac tracer injections, cardiac electrical recordings in awake and freely behaving animals, multi-electrode and transmural cardiac electrical mapping, manipulations of the cardiovascular autonomic reflexes, in vivo extracellular neural recordings, in vivo measurement of neurotransmitters and neuropeptides, single cell RNA sequencing, proteomics, tissue clearing, confocal and super-resolution imaging, and use of optogenetics to better understand the role of specific peripheral neural pathways on cardiac function. 

The lab’s breadth of research ranges from assessments in animal models to human mechanistic and clinical studies, including assessment of sex differences in the mechanisms of cardiovascular disease, in order to evaluate and develop novel, more personalized therapies for arrhythmias and heart failure.

Thank you for your interest in supporting Dr. Marmar Vaseghi’s Research fund. Your gift will help propel the development of new treatments and advance patient care. We are grateful for your generosity.

Mail: Please make checks payable to “The UCLA Foundation” with “17212C”  in the memo line.

Main Lockbox Address:
The UCLA Foundation
PO Box 7145
Pasadena, CA 91109-7145

If using FedEx/UPS/DHL:
The UCLA Foundation
Attn: Patrick Bruno
Lockbox 7145, 14005 Live Oak Ave
Irwindale, CA 91706-1300

Questions?
For more information, please contact Lindsey Walton at 424-946-6102 or LSWalton@mednet.ucla.edu